abstract：:Introduction: Vertically integrating physiology into patient care has the potential to improve clinical reasoning. Clinical Physiology Grand Rounds (CPGR) is a case-based teaching method that brings together students from all years of medical school to focus on linking clinical presentations to core basic science conc...

authors： Langer AL,Block BL,Schwartzstein RM,Richards JB

更新日期：2021-12-01 00:00:00

abstract：:The dynamic mechanism of a whole-cell model containing electrical signalling and two-compartment Ca2+ signalling in gonadotrophs is investigated. The transition from spiking to bursting by Hopf bifurcation of the fast subsystem about the slow variable is detected via the suitable parameters. When the timescale of K+ g...

authors： Xiong X,Li Y,Zheng D

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Magnetic resonance (MR) R2 relaxometry is a safe, noninvasive diagnostic modality for the evaluation of iron levels in the contents of ovarian cysts. The study aims to investigate the sensitivity and specificity of the two methods, R2 value and iron level, in diagnosing OMA patients in the validation set. M...

authors： Imanaka S,Yamada Y,Kawahara N,Kobayashi H

更新日期：2021-12-01 00:00:00

abstract：:Given the maturation of small-interfering RNA (siRNA) techniques with nanotechnology, and because overexpression of human programmed death-ligand 1 (PD-L1) is crucial for T cell inactivation and immunosuppression of the tumor microenvironment, application of siRNA-PD-L1 has demonstrated positive progress in preclinica...

authors： Wen J,Qiu N,Zhu Z,Bai P,Hu M,Qi W,Liu Y,Wei A,Chen L

更新日期：2021-12-01 00:00:00

abstract：:Currently, homosexual transmission has become one of the main routes of HIV-1 spread in China. Furthermore, about 80% Chinese men, who have sex with men (MSM), feel forced to enter eventually into heterosexual marriages due to the Chinese traditional marriage culture, which may cause HIV-1 infection in families. In th...

authors： Zhou Z,Ma P,Feng Y,Ou W,Wei M,Shao Y

更新日期：2021-12-01 00:00:00

abstract：:Glioma is a common life-threatening tumor with high malignancy and high invasiveness. LncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) was confirmed to be implicated in numerous tumors, while its biological function and mechanism have not been thoroughly understood in glioma. The gene expression was measured by RT-qPCR. Cell ...

authors： Zhang Y,Zhang Y,Wang S,Li Q,Cao B,Huang B,Wang T,Guo R,Liu N

更新日期：2021-12-01 00:00:00

abstract：:Hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) has recently aroused increasing attention, especially ST11, the predominant CRKP clone in China. Here, we report a case of hv-CRKP-associated infection and reveal the in-host evolution of its mechanism of resistance to tigecycline and polymyxin under c...

authors： Jin X,Chen Q,Shen F,Jiang Y,Wu X,Hua X,Fu Y,Yu Y

更新日期：2021-12-01 00:00:00

abstract：:Melanoma is a deadly skin cancer. Surgery is effective for early stages but there may be remnant cells. Treatments of later stages are associated with severe side effects. Moreover, a dangerous type of melanoma cannot be detected early enough for surgery. There is an urgent need for treatment with less severe side eff...

authors： Wang Y,Chang TMS

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Upper respiratory tract infection (URTI) is the most common illness in humans. Fermented milk containing probiotics can mitigate URTI symptoms. OBJECTIVE:This study tests the effect of fermented milk (Qingrun), a yogurt supplemented with Bifidobacterium animalis subsp. lactis Bl-04, on adults with URTIs who li...

authors： Zhang H,Miao J,Su M,Liu BY,Liu Z

更新日期：2021-12-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a type of non-coding RNAs generated from back splicing to enhance or inhibit the progression of multiple human cancers including osteosarcoma (OS). Although circ_0102049 has been found to be highly expressed in OS cell lines, the role and specific mechanism of circ_0102049 in OS remains un...

authors： Zhang X,Hu Z,Li W,Liu Z,Li J,Wang Z,Martin VT,Yan B,Yu B

更新日期：2021-12-01 00:00:00

abstract：:LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues. We found that the expression of ENST00000508435 was positively corre...

authors： Li L,Jin Y,Wang X,Wang L,Sun Y,Luo Y,Ni X,Lu Q,Wei W,Zhi X,Yu J,Zhu W,Zhou P

更新日期：2021-12-01 00:00:00

abstract：:To study the effect of IL-5 on the immune response and lung injury in rats with sepsis. We constructed a rat model of sepsis by cecal ligation and puncture (CLP). The rats were randomly divided into the control group, the sham group, the CLP group and the IL-5 group, with 6 rats in each group. With the induction of CL...

authors： Wei B,Chen Y,Zhou W,Li X,Shi L,Liao S

更新日期：2021-12-01 00:00:00

abstract：:Primary hyperhidrosis (PH) is a disease characterized by focal and excessive sweating.Purpose: The aim of this study was to describe the experiences of men and women with PH when seeking help for their condition.Method: A qualitative interview study with 30 men and women diagnosed with PH was conducted. Data was induc...

authors： Shayesteh A,Gerdsdorff F,Persson M,Brulin C,Nylander E

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Ircinia mutans Wilson (Irciniidae) is a sponge with antimicrobial and cytotoxic constituents. OBJECTIVE:Our objective was to characterise the cytotoxic constituents of two seasonal collections of I. mutans. MATERIALS AND METHODS:The sponges were extracted in methanol-dichloromethane and their constituents wer...

authors： Heidary Jamebozorgi F,Yousefzadi M,Firuzi O,Nazemi M,Zare S,Chandran JN,Schneider B,Baldwin IT,Jassbi AR

更新日期：2021-12-01 00:00:00

abstract：:APOBEC3 (A3) cytidine deaminases inhibit hepatitis B virus (HBV) infection and play vital roles in maintaining a variety of biochemical processes, including the regulation of protein expression and innate immunity. Emerging evidence indicates that the deaminated deoxycytidine biochemical activity of A3 proteins in sin...

authors： Zhang Y,Chen X,Cao Y,Yang Z

更新日期：2021-12-01 00:00:00

abstract：:A novel gold nanoparticle (Do-AuNP) was successfully synthesized from water extracts of traditional Chinese medicine Dendrobium officinale (DO) without using any extra chemicals regents. The physicochemical properties of Do-AuNPs were analyzed by transmission electron microscopy, dynamic light scattering, energy-dispe...

authors： Zhao W,Li J,Zhong C,Zhang X,Bao Y

更新日期：2021-12-01 00:00:00

abstract：:Colorectal cancer lymph node metastasis, which is highly associated with the patient's cancer recurrence and survival rate, has been the focus of many therapeutic strategies that are highly associated with the patient's cancer recurrence and survival rate. The popular methods for classification of lymph node metastasi...

authors： Li J,Wang P,Zhou Y,Liang H,Lu Y,Luan K

更新日期：2021-12-01 00:00:00

abstract：:Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well as the role played by different cell types present in skin, may be...

authors： Karri V,Lidén C,Fyhrquist N,Högberg J,Karlsson HL

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:The current study was designed to examine the therapeutic role of hydroalcoholic extract of Cuscuta reflexa Roxb (CRE) and Peucedanum grande C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats. METHODS:PCOS rats were treated with CRE (280 mg/kg), PG...

authors： Kausar F,Rather MA,Bashir SM,Alsaffar RM,Nabi SU,Ali SI,Goswami P,Ahmad A,Rashid S,Wali AF

更新日期：2021-12-01 00:00:00

abstract：:Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-specific abdominal fa...

authors： Guo H,Zhao W,Wang A,Li M,Ma H,Wang F,Wang Q,Ba X

更新日期：2021-12-01 00:00:00

abstract：:A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to epithelial cells. In Vero E6 cells, hypoxia reduces the protein levels of ACE2 and neuropilin-1 (NRP1),...

authors： Prieto-Fernández E,Egia-Mendikute L,Vila-Vecilla L,Bosch A,Barreira-Manrique A,Lee SY,García-Del Río A,Antoñana-Vildosola A,Jiménez-Lasheras B,Moreno-Cugnon L,Jiménez-Barbero J,Berra E,Ereño-Orbea J,Palazon A

更新日期：2021-12-01 00:00:00

abstract：:Bronchial asthma is a common respiratory disease, which is characterized by airway inflammation, remodeling and hyperresponsiveness. MicroRNAs (miRNAs), as reported, are implicated in the pathogenesis of many diseases, but how miRNAs-146a-5p (miR-146a-5p) works in asthma remains inconclusive. In this work, we proved t...

authors： Yan F,Wufuer D,Wang J,Ding J

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Achieving a deep response with induction therapy has a major impact on outcomes following autologous stem cell transplantation. Although longer and intensified induction therapy may provide better disease control, longer exposure to lenalidomide negatively affects stem cell yield. We examined the feasibility...

authors： Yoshihara S,Yoshihara K,Shimizu Y,Imado T,Takatsuka H,Kawamoto H,Misawa M,Ifuku H,Ohe Y,Okada M,Fujimori Y

更新日期：2021-12-01 00:00:00

abstract：:Orthopaedics needs a robust diagnostic tool that can help or even replace traditional radiography in bone healing assessment, thus reducing patient exposure to ionizing radiation. We used a vibrational method to assess the healing of a complex fracture treated with external fixation, exploiting a quantitative and non-...

authors： Mattei L,Di Fonzo M,Marchetti S,Di Puccio F

更新日期：2021-12-01 00:00:00

abstract：:The prevalence of ear infections and hearing i mpairment among Greenlandic children is amajor public health problem, and studies investigating the association between hearing impairment and thriving among Greenlandic children are scarce. The aim of this study was to examine the association between hearing impairment a...

authors： Friis Skovsen C,Jensen JS,Jensen RG,Schnohr C

更新日期：2021-12-01 00:00:00

abstract：:ABSTRACTCOVID-19 vaccines are being developed urgently worldwide. Here, we constructed two adenovirus vectored COVID-19 vaccine candidates of Sad23L-nCoV-S and Ad49L-nCoV-S carrying the full-length gene of SARS-CoV-2 spike protein. The immunogenicity of two vaccines was individually evaluated in mice. Specific immune ...

authors： Luo S,Zhang P,Liu B,Yang C,Liang C,Wang Q,Zhang L,Tang X,Li J,Hou S,Zeng J,Fu Y,Allain JP,Li T,Zhang Y,Li C

更新日期：2021-12-01 00:00:00

abstract：:Dysfunction of adipose tissue could lead to insulin resistance, obesity and type 2 diabetes. Thus, our present study aimed to investigate metabolites alterations in white adipose tissue (WAT) of diabetic GK rats after IT surgery. Ten-week-old male diabetic GK rats were randomly subjected to IT and Sham-IT surgery. Six...

authors： Lyu X,Yan K,Chen W,Wang Y,Zhu H,Pan H,Lin G,Wang L,Yang H,Gong F

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Overhydration is a predictor of mortality in hemodialysis (HD) patients. Bioimpedance spectroscopy (BIS) is used to determine the body composition. Extracellular Water/Total Body Water (ECW/TBW) ratio has been proposed to predict mortality. METHODS:Multicenter, prospective, observational, proof-of-concept s...

authors： Pérez-Morales R,Donate-Correa J,Martín-Núñez E,Pérez-Delgado N,Ferri C,López-Montes A,Jiménez-Sosa A,Navarro-González JF

更新日期：2021-12-01 00:00:00

abstract：:Background: This survey aims to identify the relative value and the critical components of anesthesiology letters of recommendation(LORs) from the perspective of Program Directors (PDs) and Associate/Assistant Program Directors (APDs). Knowledge and insights originating from this survey might add to the understanding ...

authors： Jn Pierre CE,Weber GM,Abramowicz AE

更新日期：2021-12-01 00:00:00

abstract：:Itraconazole (ITC), a well-tolerated antifungal drug, exerts multiple anticancer effects which justified its preclinical and clinical investigation as potential anti-cancer agent with reduced side effects. Enhancement of ITC anti-cancer efficacy would bring valuable benefits to patients. We propose herein lipid nanoca...

authors： El-Sheridy NA,El-Moslemany RM,Ramadan AA,Helmy MW,El-Khordagui LK

更新日期：2021-12-01 00:00:00

abstract：:Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation. Here, a variety of novel heterocyclic and non-heterocyclic compoun...

authors： Abd El-Hameed RH,Mahgoub S,El-Shanbaky HM,Mohamed MS,Ali SA

更新日期：2021-12-01 00:00:00

abstract：:Social accountability (SA) is an obligation for medical schools in meeting the priority health concerns of the communities they serve. To measure the integration of SA principles into medical curricula, suitable tools are needed. This study developed and validated an inventory to assess SA values within the existing c...

authors： Abdalla ME,Dash N,Shorbagi S,Taha MH

更新日期：2021-12-01 00:00:00

abstract：:We introduce a compartmental host-vector model for dengue with two viral strains, temporary cross-immunity for the hosts, and possible secondary infections. We study the conditions on existence of endemic equilibria where one strain displaces the other or the two virus strains co-exist. Since the host and vector epide...

authors： Rashkov P,Kooi BW

更新日期：2021-12-01 00:00:00

abstract：:This paper is concerned with a stochastic predator-prey model with Holling II increasing function in the predator. By applying the Lyapunov analysis method, we demonstrate the existence and uniqueness of the global positive solution. Then we show there is a stationary distribution which implies the stochastic persiste...

authors： Huang Y,Shi W,Wei C,Zhang S

更新日期：2021-12-01 00:00:00

abstract：:A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-a...

authors： Wang C,Li Y,Liu Z,Wang Z,Liu Z,Man S,Zhang Y,Bao K,Wu Y,Guan Q,Zuo D,Zhang W

更新日期：2021-12-01 00:00:00

abstract：:Polyamines are small, polycationic molecules with a hydrocarbon backbone and multiple amino groups required for optimal cell growth. The potD gene, belonging to the ABC (ATP-binding cassette) transport system potABCD, encodes the bacterial substrate-binding subunit of the polyamine transport system, playing a pivotal ...

authors： Dai K,Yang Z,Ma X,Chang YF,Cao S,Zhao Q,Huang X,Wu R,Huang Y,Xia J,Yan Q,Han X,Ma X,Wen X,Wen Y

更新日期：2021-12-01 00:00:00

abstract：INTRODUCTION:Many nursing and midwifery schools in many countries around the world awarded or still award graduation badges or pins to their graduates. All graduates from different parts of the former Kingdom of Yugoslavia and later the Republic of Yugoslavia educated in Slovenian healthcare schools received badges fro...

authors： Fischinger J,Fischinger D,Fischinger A

更新日期：2021-12-01 00:00:00

abstract：:A chimeric Eilat/ Chikungunya virus (EILV/CHIKV) was previously reported to replicate only in mosquito cells but capable of inducing robust adaptive immunity in animals. Here, we initially selected C7/10 cells to optimize the production of the chimeric virus. A two-step procedure produced highly purified virus stocks,...

authors： Adam A,Luo H,Osman SR,Wang B,Roundy CM,Auguste AJ,Plante KS,Peng BH,Thangamani S,Frolova EI,Frolov I,Weaver SC,Wang T

更新日期：2021-12-01 00:00:00

abstract：:We aimed to study the role of LINC00997 in the metastasis of colorectal cancer (CRC). LINC00997 and miR-512-3p expression in the primary colorectal cancer (NCRC) tissues and metastatic colorectal cancer (MCRC) tissues were detected using RT-qPCR. The Cancer Genome Atlas database was used to evaluate LINC00997 levels i...

authors： Shi Z,Shen C,Yu C,Yang X,Shao J,Guo J,Zhu X,Zhou G

更新日期：2021-12-01 00:00:00

abstract：:Coccidioidomycosis is endemic to California, Arizona, and Mexico. In recent years, the reported cases of coccidioidomycosis have increased in nonendemic regions. Here, we reported a case of imported pulmonary coccidioidomycosis in a Chinese patient. A 63-year-old man presented with dry cough and fatigue for 6 months, ...

authors： Yang X,Song Y,Liang T,Wang Q,Li R,Liu W

更新日期：2021-12-01 00:00:00